Theory aside, how effective is NMN in practice?
Currently, there are few clinical studies of NMN in humans. A paper published in the Journal of Endocrinology reported that Japanese scientists gave 10 healthy men aged 40 to 60 years old 100, 250 and 500 mg of NMN orally, and collected them 5 hours later. Blood and urine tests are done.
The results showed that oral administration of NMN did not have significant effects on heart rate, blood pressure, blood oxygen, body temperature, etc., nor did it bring significant changes to vision and sleep. The most critical data, NAD+ levels in tissue and plasma, was not measured in the study.
According to the current research results, it can only be said that supplementing NMN in humans may have anti-aging effects, but the evidence is insufficient.
As an important coenzyme and energy production medium in the human body, NAD+ has a huge impact on many functions of the body.
(1) Improve metabolic system. A lack of NAD+ will first lead to metabolic disorders in the human body, especially for the elderly and obese people, which will increase their probability of suffering from diabetes, cardiovascular disease, stroke, cancer and other diseases. NAD+ can activate a variety of coenzymes, inhibit the growth of fat cells, promote metabolism, and maintain body health.
(2) Enhance cardiovascular function. High blood pressure can cause the heart to enlarge and block the arteries, which can lead to stroke. And raising NAD+ levels prevents damage to the heart caused by a lack of blood. Mice were protected from abnormal heart enlargement.
(3) Repair immune function. As age increases, the immune system declines, and NAD+ plays an important role in regulating the immune system and inflammation. Supplementing NAD+ can regulate the activity of proteases such as CD38 and PARPs, leading to a reduction in pro-inflammatory cytokines and restoration of immune function.
(4) Alleviate neurodegeneration. For people suffering from Alzheimer’s disease, increasing NAD+ levels can reduce the accumulation of harmful proteins and enhance information transmission between brain cells, thereby restoring cognitive function in the brain. Raising NAD+ levels also protects brain cells from dying when there isn’t enough blood flowing to the brain.
(5) Anti-aging and extending lifespan. Birth, aging, illness and death are normal human processes, and aging cells will increase the secretion of SASP, interfere with stem cell regeneration, affect tissue repair and aggravate cellular inflammation, leading to continued aging of cell tissues. Increasing NAD+ can promote cell metabolism, enhance mitochondrial function, enhance cell activity, and effectively delay aging.
1. The mental state becomes better: After taking NMN, you feel excited or drowsy because NMN is repairing the nerve center and will produce abnormal stimulation. Most people will feel sleepy and excited at the same time. They feel energetic after getting up during the day, but tired or tired when they get up in the morning. Feeling like sleeping or being very excited are normal reactions and usually return to normal in about 30 days.
2. Faster metabolism: manifested in hunger and weight changes. Hunger is experienced by most people, because metabolism is accelerated, and hunger will follow. Hunger can lead to increased food intake, increased appetite, and weight changes. This situation occurs in the first 2 months. After 2 months, the body is in a equilibrium period, and the weight is stable after the body adjusts.
3. Increased changes in strength and endurance: Strength will be significantly improved within 2 months. Consumers can feel obvious positive changes through the grippers around them, through pull-ups or mountain climbing and running exercises.
4. Chronic diseases: neurasthenia, gout, presbyopia.
5. Changes in body shape: muscle relaxation and skin laxity are alleviated. Many people’s round faces become contoured and the skin begins to tighten. Many people will experience changes.
6. Improved immunity: Because of improved immunity, rhinitis, pharyngitis, and superficial gastritis are all improved!
8. Also by helping cerebrovascular and mitochondrial function: reducing the apoptosis of the prefrontal cortex and hippocampus in the elderly, preventing cognitive impairment caused by aging. (The changes are obvious, physical changes, real summary!)
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Post time: Apr-22-2024
