NMN is considered to be the best NAD+ precursor in the human body. However, conservative scientists believe that the absorption of NMN may also be limited to a certain extent. Only by supplementing large doses of NMN can an effective transformation effect be achieved.
To this end, Bangtai successfully developed liposome NMN, the escort express of NMN, and began large-scale mass production.
What is liposome NMN? Let’s first look at what liposomes are?
Liposomes are vesicles made of phospholipid molecules – the same molecules that make up cell membranes.
Phospholipid molecules consist of a hydrophilic phosphate head and two hydrophobic fatty acid tails. These characteristics make liposomes a carrier for both hydrophobic and hydrophilic compounds.
Due to the low absorption and bioavailability of traditional oral dietary capsules, the encapsulation of hydrophilic and hydrophobic nutrients in liposomes allows the active ingredients to bypass the destruction of the gastric system.
To release protected molecules to the site of action, the lipid bilayer fuses with other bilayers (e.g., cell membranes), delivering liposomal contents directly and intact into cells and tissues.
To put it more simply, liposomes are like a molecule-sized cash transport truck, protecting the “money (medicine)” contained in the car from being robbed on the way to the liver and other organs.
In fact, liposome products have already had quite a few success stories. Some people use liposomes to encapsulate Fisetin, and the bioavailability is increased to 27 times; the bioavailability of liposomal vitamin B-12 formula is 3-5 times higher than tablets; liposomal berberine can increase circulation time23-46 times.
So, is it necessary to encapsulate NMN in liposomes?
Judging from the confirmed mechanism of action, NMN relies on the slc12a8 transporter on small intestinal cells to transport it into the cells, and then increases the NAD+ levels in various organs and tissues of the body as the blood circulates.
However, NMN is easily degraded when moisture and temperature reach a certain height. Currently, most NMN on the market is in the form of capsules and tablets. After taking NMN capsules or tablets, most of them are degraded in the stomach. Only a small part of NMN reaches the small intestine, which is half the result with twice the effort.
After NMN is encapsulated by liposomes, NMN can be protected to reach the target location.
First of all, liposomal NMN can bypass the degradation of the digestive system, allowing it to directly enter the blood circulation and reach various organs of the body.
Secondly, liposomal NMN releases NMN molecules through membrane fusion, which delays the clearance of NMN molecules and increases their circulation time in blood vessels, reducing macrophages in the reticuloendothelial system (RES) to liposomal NMN. Digestion, and improves the retention rate of NMN molecules.
In addition, NMN encapsulated in liposomes prevents metabolism, and the drug molecules are only active after reaching the target site and being released from the liposomes.
In conclusion, liposomal NMN is an effective way to prevent the degradation of NMN in the gastric system.
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Post time: Apr-16-2024
